Original
By certification 
Chemical Structure : CFI02
CAS No.: 273735-28-7
CFI02(CFI 02;CFI-02)
Catalog No.: URK-V2341 Only Used For Lab.
CFI02 (CFI-02) is a specific inhibitor of human cytomegalovirus (HCMV) glycoprotein B-mediated fusion with IC50 of 40 nM against laboratory adapted HCMV strain AD169.
Biological Activity
CFI02 (CFI-02) is a specific inhibitor of human cytomegalovirus (HCMV) glycoprotein B-mediated fusion with IC50 of 40 nM against laboratory adapted HCMV strain AD169; reduces HCMV yield by >3 logs at 1 uM, and shows no inhibitory activity against closely related betaherpesviruses (including MCMV, simian CMV, and RCMV) (IC50>20 uM) as well as cytotoxic effect (CC50>50 uM).
Physicochemical Properties
|
M.Wt |
491.43 |
|
|
Formula |
C18H11F6N5OS2 |
|
|
CAS No. |
273735-28-7 |
|
|
Storage |
Solide Powder -20 °C 3years; 4°C 2years |
In Solvent -80°C 6 Months -20°C 1 Months |
|
Solubility |
10 mM in DMSO |
|
|
Chemical Name |
N-(4-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)phenyl)-1,2,3-thiadiazole-4-carboxamide |
|
References
1. Jones TR, et al. J Virol. 2004 Feb;78(3):1289-300.
2. Bloom JD, et al. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2929-32.
Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!
http://www.ureiko-chem.com/
